Founded or unfounded, these objections have not as yet received an adequate answer, i.e., an explanation of the possibility of a philosophy of subjectivity as constituting a reasonable addition to the philosophia perennis, a certain broadening of its perspective, without amounting instead to a simple jettisoning of the thought and gains of centuries. The writings of a Marcel, for example, do not provide such an explanation. Composed wholly within the perspective that is in question, and a little too cavalier in (...) their dismissal of scholastic thought, they cannot really come to grips with that thought, or thereby allay its reasonable suspicions. Even the work of P. de Finance is not wholly satisfactory on this point. As a reviewer of his latest book points out, P. de Finance makes constant and brilliant use of insights gained from the perspective of subjectivity, but he skirts around, without ever really meeting head on, the problems it raises. (shrink)

The difficulty with this point of view and the reason why I characterize it as false do not spring from the mere fact that thought is abstract while experience is concrete. For, on the one hand, the abstract character of thought need not be interpreted negatively, as leaving out the rich variety and profusion of the concrete world in favor of some bare common denominator. Concreteness itself can be seen as a limitation which thought overcomes.ion then becomes an enriching process, (...) a process by which the mind, out of its own superior abundance, illumines and completes the data presented to it, so that from the welter and confusion of particular instances it is able to grasp the universal and valid-for-all, and from the fugitive contingency of the concrete to redeem the abidingly true. In this light, abstractiveness is not a vice but a virtue of thought and, far from weakening the intellectualist position, serves rather to reinforce it. (shrink)

A new high‐resolution structure of a pain‐sensing ion channel, TRPA1, provides a molecular scaffold to understand channel function. Unexpected structural features include a TRP‐domain helix similar to TRPV1, a novel ligand‐binding site, and an unusual C‐terminal coiled coil stabilized by inositol hexakisphosphate (IP6). TRP‐domain helices, which structurally act as a nexus for communication between the channel gates and its other domains, may thus be a feature conserved across the entire TRP family and, possibly, other allosterically‐gated channels. Similarly, the TRPA1 antagonist‐binding (...) site could also represent a druggable location in other ion channels. Combined with known TRPA1 functional properties, the structural role for IP6 leads us to propose that polyphosphate unbinding could act as a molecular kill switch for TRPA1 inactivation. Finally, although packing of the TRPA1 membrane‐proximal region hints at a mechanism for electrophile sensing, the details of how TRPA1 responds to noxious reactive electrophiles and temperature await future studies.Also watch the Video Abstract. (shrink)

The elaboration of a complete and original system of philosophy in any age demands an intellect of great scope and power. In an age like our own, which has become increasingly hostile to systematic thought, it demands a good deal of courage as well. The Modes of Being of Mr. Weiss proves that he possesses both to a high degree.

In the academic year 1920-1921 at the University of Freiburg, Martin Heidegger gave a series of extraordinary lectures on the phenomenological significance of the religious thought of St. Paul and St. Augustine. The publication of these lectures in 1995 settled a long disputed question, the decisive role played by Christian theology in the development of Heidegger’s philosophy. The lectures present a special challenge to readers of Heidegger and theology alike. Experimenting with language and drawing upon a wide range of now (...) obscure authors, Heidegger is finding his way to Being and Time through the labyrinth of his Catholic past and his increasing fascination with Protestant theology. A Companion to Heidegger's Phenomenology of Religious Life is written by an international team of Heidegger specialists. (shrink)

There is, in the Ramsey Archive at the Hillman Library of the University of Pittsburgh, a note, written in 1929, in Ramsey's hand and mostly in German, consisting of twenty paragraphs the contents...

This study of three central themes in the logic of Alexander of Aphrodisias, the greatest of the ancient Aristotelian commentators, provides insight not only into Aristotle's logical writings but also into the tradition of scholarship which they spawned.

ALBERT EINSTEIN’S CONNECTIONS WITH SPINOZA’S PHILOSOPHY The paper aims to analyze the influence of Baruch Spinoza’s philosophy on Albert Einstein’s work, in particular his physics. Einstein was a man of genius personality of contemporary physics, but we can see him as a prominent philosopher, too. He studied the philosophical works of Kant, Leibniz, Hume and other modern philosophers. But his most preferred thinker was Baruch Spinoza. Einstein knew very well Spinoza’s main book, Ethics. He accepted Spinoza’s concepts of human being (...) and the dignity of man in the history of the world. The concept of God proposed by the author of Ethics was very important for Einstein. Spinoza’s inspiring philosophy is present in Einstein’s vision of the universe and in his deterministic view on quantum mechanics. This problem is reflected in the paper too. Keywords: BARUCH SPINOZA, ALBERT EINSTEIN, CONTEMPORARY PHYSICS, UNIVERSE. (shrink)

Introduction -- Tending the dark fire: the Boehmian notion of drive -- The night-side of nature: the early Schellingian unconscious -- The speculative psychology of dissociation: the later Schellingian unconscious -- Schellingian libido theory.